In a separate study, mice received IV injection of an imaging dose of MnCl 2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. ![]() (0.5 and 0.8%ID/g), but to a much greater degree from IV injection (6.8 and 10%ID/g). Uptake in salivary gland and pancreas were observed at 1 d p.i. Manganese is known to cross the blood-brain barrier, as confirmed in our studies following IV injection (0.86%ID/g, 1 d p.i.) and following inhalation of aerosol, (0.31%ID/g, 1 d p.i.). In both trials, we observed uptake in lungs and thyroid at 1 d p.i. Ex vivo biodistribution was performed at 1 h and 1 d post-injection/inhalation (p.i.). An aqueous solution of MnCl 2 was nebulized into a closed chamber more ยป with openings through which mice inhaled the aerosol, and a separate cohort of mice received intravenous (IV) injections of MnCl 2. In this study, we produced the positron-emitting radionuclide 52Mn (t 1/2 = 5.6 d) by proton bombardment (E p<15 MeV) of chromium metal, followed by solid-phase isolation by cation-exchange chromatography. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly at the trace level, can be challenging. Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. ![]() Louis, MO (United States) Sponsoring Org.: USDOE National Nuclear Security Administration (NNSA) National Institutes of Health (NIH) OSTI Identifier: 1344116 Alternate Identifier(s): OSTI ID: 1250574 Grant/Contract Number: NA0000979 Resource Type: Journal Article: Accepted Manuscript Journal Name: Applied Radiation and Isotopes Additional Journal Information: Journal Volume: 96 Journal Issue: C Journal ID: ISSN 0969-8043 Publisher: Elsevier Country of Publication: United States Language: English Subject: 07 ISOTOPE AND RADIATION SOURCES 52Mn 52mMn 54Mn Cross-section Solid target Radiometal PET isotopes Isotope = , ![]() Publication Date: Research Org.: Washington Univ., St. of Biomedical Engineering Washington Univ.
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